کلیه مصنوعی و بررسی 916 مورد درمان بوسیله آن
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Dmd063297 916..921
4-Aminobiphenyl (ABP), a prototypical aromatic amine carcinogen in rodents and humans, requires bioactivation to manifest its toxic effects. A traditional model of ABP bioactivation, based on in vitro enzyme kinetic evidence, had postulated initial N-hydroxylation by the cytochrome P450 isoform CYP1A2. This is followed by phase 2 O-conjugation and hydrolysis to form a reactive nitrenium ion tha...
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Journal title
volume 18 issue None
pages 752- 771
publication date 1961-03
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